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Article

Gene expression signatures predict response to therapy with growth hormone

27 May 2021

Abstract excerpt

Recombinant human growth hormone (r-hGH) is used as a therapeutic agent for disorders of growth including growth hormone deficiency (GHD) and Turner syndrome (TS). Treatment is costly and current methods to model response are inexact. GHD (n = 71) and TS patients (n = 43) were recruited to study response to r-hGH over 5 years. Analysis was performed using 1219 genetic markers and baseline (pre-treatment) blood...

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PMID: 34045667
DOI: 10.1038/s41397-021-00237-5

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