Article
Association of the (CA)n repeat polymorphism of insulin-like growth factor-I and -202 A/C IGF-binding protein-3 promoter polymorphism with adult height in patients with severe growth hormone deficiency.
Clinical endocrinology - 1 May 2012
Miletta Maria Consolata, Scheidegger Ursina A, Giordano Mara, Bozzola Mauro, Pagani Sara, Bona Gianni, Dattani Mehul, Hindmarsh Peter C, Petkovic Vibor, Oser-Meier Monika, Flück Christa E, Mullis Primus-E
Abstract excerpt
OBJECTIVE: A number of mathematical models for predicting growth and final height outcome have been proposed to enable the clinician to 'individualize' growth-promoting treatment. However, despite optimizing these models, many patients with isolated growth hormone deficiency (IGHD) do not reach their target height. The aim of this study was to analyse the impact of polymorphic genotypes [CA repeat promoter...
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