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Article

The interactive effect of GHR-exon 3 and -202 A/C IGFBP3 polymorphisms on rhGH responsiveness and treatment outcomes in patients with Turner syndrome.

The Journal of clinical endocrinology and metabolism - 1 Apr 2012

Braz Adriana F, Costalonga Everlayny F, Montenegro Luciana R, Trarbach Ericka B, Antonini Sonir R R, Malaquias Alexsandra C, Ramos Ester S, Mendonca Berenice B, Arnhold Ivo J P, Jorge Alexander A L

Abstract excerpt

CONTEXT: There is great interindividual variability in the response to recombinant human (rh) GH therapy in patients with Turner syndrome (TS). Ascertaining genetic factors can improve the accuracy of growth response predictions. OBJECTIVE: The objective of the study was to assess the individual and combined influence of GHR-exon 3 and -202 A/C IGFBP3 polymorphisms on the short- and long-term outcomes of rhGH...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22278433
DOI: 10.1210/jc.2011-2521

Genes

GHR
IGFBP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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The interactive effect of GHR-exon 3 and -202 A/C IGFBP3 polymorphisms on rhGH responsiveness and treatment outcomes in patients with Turner syndrome.PMID 22278433Read ↗

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The common exon 3 polymorphism of the growth hormone receptor gene and the effect of growth hormone therapy on growth in Korean patients with Turner syndrome.Semantic proximity Read ↗

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Homozygosity of the d3-growth hormone receptor polymorphism is associated with a high total effect of GH on growth and a low BMI in girls with Turner syndrome.Semantic proximity Read ↗

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Clinical and Molecular Genetic Analysis of Children with Severe Short Stature due to Isolated Growth Hormone Deficiency: Insights from a South Indian Cohort and Predictors of Growth Response.Semantic proximity Read ↗

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