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Engineered cytidine triphosphate synthetase with reduced product inhibition.

Protein engineering, design & selection : PEDS - 1 Jul 2014

Zhu Mengzhu, Sun Wujin, Wang Yan, Meng Jie, Zhang Dalu, Guo Ting, Ouyang Pingkai, Ying Hanjie, Xie Jingjing

Abstract excerpt

Cytidine triphosphate (CTP) synthetase (CTPS) (EC number 6.3.4.2) is a key enzyme involved in de novo synthesis of CTP. It catalyzes the rate-limiting step of the process due to the product inhibition effects on the enzyme. In this study, a novel CTPS from Corynebacterium glutamicum ATCC 13032 (CgCTPS) was cloned, expressed and characterized. A series of mutagenesis in its N-terminal ammonia ligase (ALase) domain...

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PMID: 24902851
DOI: 10.1093/protein/gzu019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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