Generation of mutant threonine dehydratase and its effects on isoleucine synthesis in Corynebacterium glutamicum.

doi:10.1007/s11274-015-1885-3

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Article

Generation of mutant threonine dehydratase and its effects on isoleucine synthesis in Corynebacterium glutamicum.

World journal of microbiology & biotechnology - 1 Sept 2015

Guo Yanfeng, Xu Jianzhong, Han Mei, Zhang Weiguo

Abstract excerpt

Isoleucine synthesis is strongly regulated by its end product (isoleucine) in Corynebacterium glutamicum, especially at threonine dehydratase (TD) node. Multiple alignments of TD sequences of C. glutamicum and other sources were performed. According to the structural analysis, three TD variants were constructed by site-directed mutagenesis. These TD variants improved the performance of the holoenzyme. The...

Topics

Bacterial Proteins
Corynebacterium glutamicum
Humans
Isoleucine
Mutation
Protein Engineering
Sequence Alignment
Threonine Dehydratase

Source

Open in PubMed

Identifiers

PMID: 26070433
DOI: 10.1007/s11274-015-1885-3

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