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Article

Constitutive hepcidin expression prevents iron overload in a mouse model of hemochromatosis.

Nature genetics - 1 May 2003

Nicolas Gaël, Viatte Lydie, Lou Dan-Qing, Bennoun Myriam, Beaumont Carole, Kahn Axel, Andrews Nancy C, Vaulont Sophie

Abstract excerpt

Hereditary hemochromatosis is a prevalent genetic disorder of iron hyperabsorption leading to hyperferremia, tissue iron deposition and complications including cirrhosis, hepatocarcinoma, cardiomyopathy and diabetes. Most individuals affected with hereditary hemochromatosis are homozygous with re...

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Topics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12704388
DOI: 10.1038/ng1150

Genes

HFE
HAMP

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12704388-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Constitutive hepcidin expression prevents iron overload in a mouse model of hemochromatosis.PMID 12704388Read ↗

Hfe acts in hepatocytes to prevent hemochromatosis.Semantic proximity Read ↗

Mechanisms of Iron Accumulation in Hereditary HemochromatosisSemantic proximity Read ↗

Hepcidin, the recently identified peptide that appears to regulate iron absorption.Semantic proximity Read ↗

New insights into iron homeostasis through the study of non-HFE hereditary haemochromatosis.Semantic proximity Read ↗

Pathogenesis of hereditary hemochromatosis.Semantic proximity Read ↗

Hepcidin, a candidate modifier of the hemochromatosis phenotype in mice.Semantic proximity Read ↗

The transferrin receptor modulates Hfe-dependent regulation of hepcidin expression.Semantic proximity Read ↗

HFE gene knockout produces mouse model of hereditary hemochromatosisSemantic proximity Read ↗

Hepcidin expression does not rescue the iron-poor phenotype of Kupffer cells in Hfe-null mice after liver transplantation.Semantic proximity Read ↗

Targeted disruption of hepcidin in the liver recapitulates the hemochromatotic phenotype.Semantic proximity Read ↗

Transgenic HFE-dependent induction of hepcidin in mice does not require transferrin receptor-2.Semantic proximity Read ↗

Regulation of iron absorption in Hfe mutant mice.Semantic proximity Read ↗

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