Article
Chromosomal localization, hematologic characterization, and iron metabolism of the hereditary erythroblastic anemia (hea) mutant mouse.
Blood - 1 Sept 2004
White Robert A, McNulty Steven G, Roman Shelly, Garg Uttam, Wirtz Eric, Kohlbrecher Deanna, Nsumu Ndona N, Pinson David, Gaedigk Roger, Blackmore Krista, Copple Angela, Rasul Sidrah, Watanabe Masayo, Shimizu Koji
Abstract excerpt
Understanding iron metabolism has been enhanced by identification of genes for iron deficiency mouse mutants. We characterized the genetics and iron metabolism of the severe anemia mutant hea (hereditary erythroblastic anemia), which is lethal at 5 to 7 days. The hea mutation results in reduced red blood cell number, hematocrit, and hemoglobin. The hea mice also have elevated Zn protoporphyrin and serum iron....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.