Article
Hypoxia-inducible factor-2α mediates the adaptive increase of intestinal ferroportin during iron deficiency in mice.
Gastroenterology - 1 Jun 2011
Taylor Matthew, Qu Aijuan, Anderson Erik R, Matsubara Tsutomu, Martin Angelical, Gonzalez Frank J, Shah Yatrik M
Abstract excerpt
BACKGROUND & AIMS: Iron deficiency and iron overload affect over a billion people worldwide. Dietary iron absorption in the small intestine is required for systemic iron homeostasis. Ferroportin (FPN) is the only characterized, mammalian, basolateral iron exporter. Despite the importance of FPN in maintaining iron homeostasis, its in vivo mechanisms of regulation are unclear. METHODS: Systemic iron homeostasis...
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