Article
Modulation of intestinal sulfur assimilation metabolism regulates iron homeostasis.
Proceedings of the National Academy of Sciences of the United States of America - 20 Mar 2018
Hudson Benjamin H, Hale Andrew T, Irving Ryan P, Li Shenglan, York John D
Abstract excerpt
Sulfur assimilation is an evolutionarily conserved pathway that plays an essential role in cellular and metabolic processes, including sulfation, amino acid biosynthesis, and organismal development. We report that loss of a key enzymatic component of the pathway, bisphosphate 3'-nucleotidase (Bpnt1), in mice, both whole animal and intestine-specific, leads to iron-deficiency anemia. Analysis of mutant enterocytes...
Topics
- Animals
- Gene Expression Regulation, Enzymologic
- Genotype
- Homeostasis
- Intestines
- Iron
- Mice
- Mice, Knockout
- Nucleotidases
- Sulfur