Article
Genetic disruption of leucine rich repeat transmembrane protein 4 like 1 induces a pro-social behavioural phenotype in zebrafish.
Neurobiology of disease - 1 Feb 2026
Hillman Courtney, Petracco Giulia, Fontana Barbara D, Scaia María Florencia, Dalla-Vecchia Elisa, Wetton Jon H, Norton William H J, Parker Matthew O, Reichmann Florian
Abstract excerpt
BACKGROUND: In humans, disruptions in social behaviour are characteristic of many neuropsychiatric disorders, where both genetic risk factors and synaptic dysfunctions can contribute to the phenotype. Among the genes implicated in synaptic regulation, the synaptic adhesion protein leucine-rich repeat transmembrane protein 4 (LRRTM4) has been identified as a key player in maintaining synaptic function and neuronal...
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