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Article

Characterization of PTPRG in knockdown and phosphatase-inactive mutant mice and substrate trapping analysis of PTPRG in mammalian cells.

PloS one - 1 Jan 2012

Zhang Wandong, Savelieva Katerina V, Tran David T, Pogorelov Vladimir M, Cullinan Emily B, Baker Kevin B, Platt Kenneth A, Hu Sean, Rajan Indrani, Xu Nianhua, Lanthorn Thomas H

Abstract excerpt

Receptor tyrosine phosphatase gamma (PTPRG, or RPTPγ) is a mammalian receptor-like tyrosine phosphatase which is highly expressed in the nervous system as well as other tissues. Its function and biochemical characteristics remain largely unknown. We created a knockdown (KD) line of this gene in mouse by retroviral insertion that led to 98-99% reduction of RPTPγ gene expression. The knockdown mice displayed...

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Identifiers

PMID: 23029056
DOI: 10.1371/journal.pone.0045500
PMCID: PMC3447766

Genes

PTPRG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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