Article

Inhibition of protein tyrosine phosphatase PTP1B function ameliorates pathophysiological deficits in Rett Syndrome

2026-06-08

Abstract excerpt

<h4>ABSTRACT</h4> Rett syndrome (RTT) is a severe neurodevelopmental disorder in which current therapeutic strategies remain largely focused on providing symptomatic relief without addressing underlying disease mechanisms. In contrast, we have identified the protein tyrosine phosphatase PTP1B as a mechanism-based therapeutic target and evaluated a class of selective, allosteric small-molecule inhibitors in female...

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Literature Corpus work: b89f3b60-6982-5651-91b7-3a68ef9966f9
DOI: 10.64898/2026.06.04.730096

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