Article
Mutation of the Thap4 gene causes dwarfism and testicular anomalies in rats and mice.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Jun 2024
Katayama Kentaro, Ito Junya, Murakami Rei, Yamashita Ayako, Sasajima Hotaka, Narahashi Satomi, Chiba Junko, Yamamoto Ichiro, Fujii Wataru, Tochigi Yuki, Suzuki Hiroetsu
Abstract excerpt
The petit (pet) locus is associated with dwarfism, testicular anomalies, severe thymic hypoplasia, and high postnatal lethality, which are inherited in autosomal recessive mode of inheritance in rats with a Wistar strain genetic background. Linkage analysis localized the pet locus between 98.7 Mb and 101.2 Mb on rat chromosome 9. Nucleotide sequence analysis identified 2 bp deletion in exon 2 of the Thap4 gene as...
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