Article
Abnormal social behaviors and altered gene expression rates in a mouse model for Potocki-Lupski syndrome.
Human molecular genetics - 15 Aug 2008
Molina Jessica, Carmona-Mora Paulina, Chrast Jacqueline, Krall Paola M, Canales César P, Lupski James R, Reymond Alexandre, Walz Katherina
Abstract excerpt
The Potocki-Lupski syndrome (PTLS) is associated with a microduplication of 17p11.2. Clinical features include multiple congenital and neurobehavioral abnormalities and autistic features. We have generated a PTLS mouse model, Dp(11)17/+, that recapitulates some of the physical and neurobehavioral phenotypes present in patients. Here, we investigated the social behavior and gene expression pattern of this mouse...
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