Article
GxE interactions between FOXO genotypes and drinking tea are significantly associated with prevention of cognitive decline in advanced age in China.
The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Apr 2015
Zeng Yi, Chen Huashuai, Ni Ting, Ruan Rongping, Feng Lei, Nie Chao, Cheng Lingguo, Li Yang, Tao Wei, Gu Jun, Land Kenneth C, Yashin Anatoli, Tan Qihua, Yang Ze, Bolund Lars, Yang Huanming, Hauser Elizabeth, Willcox D Craig, Willcox Bradley J, Tian Xiao-Li, Vaupel James W
Abstract excerpt
Logistic regression analysis based on data from 822 Han Chinese oldest old aged 92+ demonstrated that interactions between carrying FOXO1A-266 or FOXO3-310 or FOXO3-292 and tea drinking at around age 60 or at present time were significantly associated with lower risk of cognitive disability at advanced ages. Associations between tea drinking and reduced cognitive disability were much stronger among carriers of...
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