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Article

Comparing Effects of FOXO3 and Residing in Urban Areas on Longevity: A Gene-Environment Interaction Study.

The journals of gerontology. Series A, Biological sciences and medical sciences - 12 Aug 2022

Ji John S, Liu Linxin, Yan Lijing L, Zeng Yi

Abstract excerpt

Forkhead box O3 (FOXO3) is a candidate longevity gene. Urban residents are also positively associated with longer life expectancy. We conducted a gene-environment interaction to assess the synergistic effect of FOXO3 and urban/rural environments on mortality. We included 3 085 older adults from the Chinese Longitudinal Healthy Longevity Survey. We used single-nucleotide polymorphisms (SNPs) rs2253310, rs2802292,...

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Identifiers

PMID: 34875051
DOI: 10.1093/gerona/glab362
PMCID: PMC9373955

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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