Article
A gene-environment interplay between omega-3 supplementation and APOE ε4 provides insights for Alzheimer's disease precise prevention amongst high-genetic-risk population.
European journal of neurology - 1 Feb 2022
Li Lin, Xu Wei, Tan Chen-Chen, Cao Xi-Peng, Wei Bao-Zhen, Dong Cheng-Wen, Tan Lan
Abstract excerpt
BACKGROUND AND PURPOSE: The present study aimed to explore whether and how omega-3 (ω-3) supplementation could interact with genetic factors to modulate cognitive functions, amyloid pathologies, and Alzheimer's disease (AD) risk. METHODS: A total of 1,670 non-demented participants (mean age 73 years, 47% females, 41% APOE ε4 carriers) were followed up for 10 years. Hierarchical regressions, linear mixed-effects...
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