Article
Transcription of the activating receptor NKG2D in natural killer cells is regulated by STAT3 tyrosine phosphorylation.
Blood - 17 Jul 2014
Zhu Shiguo, Phatarpekar Prasad V, Denman Cecele J, Senyukov Vladimir V, Somanchi Srinivas S, Nguyen-Jackson Hoainam T, Mace Emily M, Freeman Alexandra F, Watowich Stephanie S, Orange Jordan S, Holland Steven M, Lee Dean A
Abstract excerpt
Signal transducer and activator of transcription 3 (STAT3) is considered a negative regulator of inflammation, as inhibition of STAT3 signaling enhances antitumor immunity. However, STAT3 activation is a key oncogenic pathway in natural killer (NK)-lineage large granular lymphomas, and we recently reported enhanced proliferation and function of human NK cells activated with IL-21, which signals primarily through...
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