STAT3 mutations unify the pathogenesis of chronic lymphoproliferative disorders of NK cells and T-cell large granular lymphocyte leukemia.

doi:10.1182/blood-2012-06-435297

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Article

STAT3 mutations unify the pathogenesis of chronic lymphoproliferative disorders of NK cells and T-cell large granular lymphocyte leukemia.

Blood - 11 Oct 2012

Jerez Andres, Clemente Michael J, Makishima Hideki, Koskela Hanna, Leblanc Francis, Peng Ng Kwok, Olson Thomas, Przychodzen Bartlomiej, Afable Manuel, Gomez-Segui Ines, Guinta Kathryn, Durkin Lisa, Hsi Eric D, McGraw Kathy, Zhang Dan, Wlodarski Marcin W, Porkka Kimmo, Sekeres Mikkael A, List Alan, Mustjoki Satu, Loughran Thomas P, Maciejewski Jaroslaw P

Abstract excerpt

Chronic lymphoproliferative disorders of natural killer cells (CLPD-NKs) and T-cell large granular lymphocytic leukemias (T-LGLs) are clonal lymphoproliferations arising from either natural killer cells or cytotoxic T lymphocytes (CTLs). We have investigated for distribution and functional significance of mutations in 50 CLPD-NKs and 120 T-LGL patients by direct sequencing, allele-specific PCR, and microarray...

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PMID: 22859607
DOI: 10.1182/blood-2012-06-435297
PMCID: PMC3471515

Genes

STAT3

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