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Article

Tumor cell recognition by the NK cell activating receptor NKG2D

31 Oct 2008

Abstract excerpt

Evidence for increased tumor incidence in NKG2D-deficient mice has set NKG2D as the first innate immune receptor implicated in immunosurveillance of tumors. In this viewpoint article, we discuss recent genetic insight into NKG2D-mediated suppression of spontaneous tumor development in the context of NKG2D signaling properties. Moreover, we identify unresolved issues and consider how an understanding of...

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PMID: 18979516
DOI: 10.1002/eji.200838833

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