Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human microRNA-1245 down-regulates the NKG2D receptor in natural killer cells and impairs NKG2D-mediated functions

4 Apr 2012

Abstract excerpt

BACKGROUND: NKG2D is an activating receptor expressed by natural killer and T cells, which have crucial functions in tumor and microbial immunosurveillance. Several cytokines have been identified as modulators of NKG2D receptor expression. However, little is known about NKG2D gene regulation. In this study, we found that microRNA 1245 attenuated the expression of NKG2D in natural killer cells. DESIGN AND METHODS:...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CAR-T cell therapy research
Share to Immune Cell Function and Interaction
Share to MicroRNA in disease regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22491735
DOI: 10.3324/haematol.2011.058529

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human microRNA-1245 down-regulates the NKG2D receptor in natural killer cells and impairs NKG2D-mediated functionsPMID 22491735Read ↗

NKG2D signaling in cancer immunosurveillanceSemantic proximity Read ↗

A Truncated Human NKG2D Splice Isoform Negatively Regulates NKG2D-Mediated FunctionSemantic proximity Read ↗

Advances in NKG2D ligand recognition and responses by NK cellsSemantic proximity Read ↗

NKG2D Ligands in Tumor Immunity: Two Sides of a CoinSemantic proximity Read ↗

The Role and Regulation of the NKG2D/NKG2D Ligand System in CancerSemantic proximity Read ↗

Immunobiology and Conflicting Roles of the Human NKG2D Lymphocyte Receptor and Its Ligands in CancerSemantic proximity Read ↗

Tumor cell recognition by the NK cell activating receptor NKG2DSemantic proximity Read ↗

Genetics, genomics, and evolutionary biology of NKG2D ligands.Semantic proximity Read ↗

Regulation of Ligands for the NKG2D Activating ReceptorSemantic proximity Read ↗

Regulation of the PD-1/PD-L1 axis and NK cell dysfunction by exosomal miR-552-5p in gastric cancerSemantic proximity Read ↗

Effect of NKG2D ligand expression on host immune responsesSemantic proximity Read ↗

Transcription of the activating receptor NKG2D in natural killer cells is regulated by STAT3 tyrosine phosphorylation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.