Article
Implications of a 'Third Signal' in NK Cells.
Cells - 31 Jul 2021
Khalil Mohamed, Wang Dandan, Hashemi Elaheh, Terhune Scott S, Malarkannan Subramaniam
Abstract excerpt
Innate and adaptive immune systems are evolutionarily divergent. Primary signaling in T and B cells depends on somatically rearranged clonotypic receptors. In contrast, NK cells use germline-encoded non-clonotypic receptors such as NCRs, NKG2D, and Ly49H. Proliferation and effector functions of T and B cells are dictated by unique peptide epitopes presented on MHC or soluble humoral antigens. However, in NK...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.