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NKG2D Ligands in Tumor Immunity: Two Sides of a Coin

4 Mar 2015

Abstract excerpt

The activating/co-stimulatory receptor NKG2D (natural-killer group 2, member D) is expressed on the surface of all human NK, NKT, CD8(+) T, and subsets of γδ(+) T cells. The significance of NKG2D function in tumor immunity has been well demonstrated in experimental animal models. However, the role of human NKG2D ligands in regulating tumor immunity and cancer prognosis had been controversial in the literature. In...

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PMID: 25788898
DOI: 10.3389/fimmu.2015.00097

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