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Article

NKG2D signaling in cancer immunosurveillance

8 Feb 2014

Abstract excerpt

The immune system is able to detect and eliminate transformed cells. The activating receptor NKG2D is particularly relevant for cancer immunosurveillance. NKG2D ligand expression renders tumor cells more susceptible to be killed by NK and T cells, and correlates with the clinical outcome of the disease. However, tumors develop mechanisms to overcome the NKG2D-mediated immune response, which has been associated...

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PMID: 24615398
DOI: 10.1002/ijc.28775

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