Article
Allele-specific DNA methylation maps in monozygotic twins discordant for psychiatric disorders reveal that disease-associated switching at the EIPR1 regulatory loci modulates neural function.
Molecular psychiatry - 1 Nov 2021
Li Qiyang, Wang Zhongju, Zong Lu, Ye Linyan, Ye Junping, Ou Haiyan, Jiang Tingyun, Guo Bo, Yang Qiong, Liang Wenquan, Zhang Jian, Long Yong, Zheng Xianzhen, Hou Yu, Wu Fengchun, Zhou Lin, Li Shufen, Huang Xingbing, Zhao Cunyou
Abstract excerpt
The non-Mendelian features of phenotypic variations within monozygotic twins are likely complicated by environmental modifiers of genetic effects that have yet to be elucidated. Here, we performed methylome and genome analyses of blood DNA from psychiatric disorder-discordant monozygotic twins to study how allele-specific methylation (ASM) mediates phenotypic variations. We identified that thousands of genetic...
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