Epigenetic differences arise during the lifetime of monozygotic twins.

doi:10.1073/pnas.0500398102

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Article

Epigenetic differences arise during the lifetime of monozygotic twins.

Proceedings of the National Academy of Sciences of the United States of America - 26 Jul 2005

Fraga Mario F, Ballestar Esteban, Paz Maria F, Ropero Santiago, Setien Fernando, Ballestar Maria L, Heine-Suñer Damia, Cigudosa Juan C, Urioste Miguel, Benitez Javier, Boix-Chornet Manuel, Sanchez-Aguilera Abel, Ling Charlotte, Carlsson Emma, Poulsen Pernille, Vaag Allan, Stephan Zarko, Spector Tim D, Wu Yue-Zhong, Plass Christoph, Esteller Manel

Abstract excerpt

Monozygous twins share a common genotype. However, most monozygotic twin pairs are not identical; several types of phenotypic discordance may be observed, such as differences in susceptibilities to disease and a wide range of anthropomorphic features. There are several possible explanations for these observations, but one is the existence of epigenetic differences. To address this issue, we examined the global...

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PMID: 16009939
DOI: 10.1073/pnas.0500398102
PMCID: PMC1174919

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