Article
Differences between germline genomes of monozygotic twins.
Nature genetics - 1 Jan 2021
Jonsson Hakon, Magnusdottir Erna, Eggertsson Hannes P, Stefansson Olafur A, Arnadottir Gudny A, Eiriksson Ogmundur, Zink Florian, Helgason Einar A, Jonsdottir Ingileif, Gylfason Arnaldur, Jonasdottir Adalbjorg, Jonasdottir Aslaug, Beyter Doruk, Steingrimsdottir Thora, Norddahl Gudmundur L, Magnusson Olafur Th, Masson Gisli, Halldorsson Bjarni V, Thorsteinsdottir Unnur, Helgason Agnar, Sulem Patrick, Gudbjartsson Daniel F, Stefansson Kari
Abstract excerpt
Despite the important role that monozygotic twins have played in genetics research, little is known about their genomic differences. Here we show that monozygotic twins differ on average by 5.2 early developmental mutations and that approximately 15% of monozygotic twins have a substantial number of these early developmental mutations specific to one of them. Using the parents and offspring of twins, we...
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