Article
Large-scale association study identifies ICAM gene region as breast and prostate cancer susceptibility locus.
Cancer research - 15 Dec 2004
Kammerer Stefan, Roth Richard B, Reneland Richard, Marnellos George, Hoyal Carolyn R, Markward Nathan J, Ebner Florian, Kiechle Marion, Schwarz-Boeger Ulrike, Griffiths Lyn R, Ulbrich Christian, Chrobok Korbinian, Forster Gerhard, Praetorius Georg M, Meyer Peter, Rehbock Joachim, Cantor Charles R, Nelson Matthew R, Braun Andreas
Abstract excerpt
We conducted a large-scale association study to identify genes that influence nonfamilial breast cancer risk using a collection of German cases and matched controls and >25,000 single nucleotide polymorphisms located within 16,000 genes. One of the candidate loci identified was located on chromosome 19p13.2 [odds ratio (OR) = 1.5, P = 0.001]. The effect was substantially stronger in the subset of cases with...
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