Article
Genetic variation in the CYP2B6 gene is related to circulating 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) concentrations: an observational population-based study.
Environmental health : a global access science source - 8 May 2014
Penell Johanna, Lind Lars, Fall Tove, Syvänen Anne-Christine, Axelsson Tomas, Lundmark Per, Morris Andrew P, Lindgren Cecilia, Mahajan Anubha, Salihovic Samira, van Bavel Bert, Ingelsson Erik, Lind P Monica
Abstract excerpt
BACKGROUND: Since human CYP2B6 has been identified as the major CYP enzyme involved in the metabolism of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) and that human 2B6 is a highly polymorphic CYP, with known functional variants, we evaluated if circulating concentrations of a major brominated flame retardant, BDE-47, were related to genetic variation in the CYP2B6 gene in a population sample. METHODS: In the...
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