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Article

CYP2B6*6 is associated with increased breast cancer risk.

International journal of cancer - 15 Jan 2014

Justenhoven Christina, Pentimalli Daniela, Rabstein Sylvia, Harth Volker, Lotz Anne, Pesch Beate, Brüning Thomas, Dörk Thilo, Schürmann Peter, Bogdanova Natalia, Park-Simon Tjoung-Won, Couch Fergus J, Olson Janet E, Fasching Peter A, Beckmann Matthias W, Häberle Lothar, Ekici Arif, Hall Per, Czene Kamilla, Liu Janjun, Li Jingmei, Baisch Christian, Hamann Ute, Ko Yon-Dschun, Brauch Hiltrud

Abstract excerpt

The cytochrome P450 2B6 (CYP2B6) is involved in the metabolism of testosterone. Functional changes in this enzyme may influence endogenous hormone exposure, which has been associated with risk of breast cancer. To assess potential associations between two functional polymorphisms CYP2B6_516_G>T (rs3745274) and CYP2B6_785_A>G (rs2279343) and breast cancer risk, we established a specific matrix-assisted laser...

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Identifiers

PMID: 23824676
DOI: 10.1002/ijc.28356
PMCID: PMC3883876

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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