Article
Mutation in KERA identified by linkage analysis and targeted resequencing in a pedigree with premature atherosclerosis.
PloS one - 1 Jan 2014
Maiwald Stephanie, Sivapalaratnam Suthesh, Motazacker Mahdi M, van Capelleveen Julian C, Bot Ilze, de Jager Saskia C, van Eck Miranda, Jolley Jennifer, Kuiper Johan, Stephens Jonathon, Albers Cornelius A, Vosmeer C Ruben, Kruize Heleen, Geerke Daan P, van der Wal Allard C, van der Loos Chris M, Kastelein John J P, Trip Mieke D, Ouwehand Willem H, Dallinga-Thie Geesje M, Hovingh G Kees
Abstract excerpt
AIMS: Genetic factors explain a proportion of the inter-individual variation in the risk for atherosclerotic events, but the genetic basis of atherosclerosis and atherothrombosis in families with Mendelian forms of premature atherosclerosis is incompletely understood. We set out to unravel the mo...
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