Article
Aging syndrome genes and premature coronary artery disease.
BMC medical genetics - 31 Oct 2005
Low Adrian F, O'Donnell Christopher J, Kathiresan Sekar, Everett Brendan, Chae Claudia U, Shaw Stanley Y, Ellinor Patrick T, MacRae Calum A
Abstract excerpt
BACKGROUND: Vascular disease is a feature of aging, and coronary vascular events are a major source of morbidity and mortality in rare premature aging syndromes. One such syndrome is caused by mutations in the lamin A/C (LMNA) gene, which also has been implicated in familial insulin resistance. A second gene related to premature aging in man and in murine models is the KLOTHO gene, a hypomorphic variant of which...
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