Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Notchless is required for axial skeleton formation in mice.

PloS one - 1 Jan 2014

Beck-Cormier Sarah, Escande Marie, Souilhol Céline, Vandormael-Pournin Sandrine, Sourice Sophie, Pilet Paul, Babinet Charles, Cohen-Tannoudji Michel

Abstract excerpt

Maintenance of cell survival is essential for proper embryonic development. In the mouse, Notchless homolog 1 (Drosophila) (Nle1) is instrumental for survival of cells of the inner cell mass upon implantation. Here, we analyze the function of Nle1 after implantation using the Meox2(tm1(cre)Sor) mouse that expresses the Cre recombinase specifically in the epiblast at E5.5. First, we find that NLE1 function is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caspase 3
Share to Embryo Implantation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Embryo, Mammalian

Share to Microfilament Proteins

Share to Neural Tube

Share to Organogenesis

Share to Somites

Source

Open in PubMed Open full text

Identifiers

PMID: 24875805
DOI: 10.1371/journal.pone.0098507
PMCID: PMC4038589

Genes

NLE1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Notchless is required for axial skeleton formation in mice.PMID 24875805Read ↗

The concerted action of Meox homeobox genes is required upstream of genetic pathways essential for the formation, patterning and differentiation of somites.Semantic proximity Read ↗

Temporal loss of En1 during limb development causes distinct phenotypes.Semantic proximity Read ↗

Greb1 is required for axial elongation and segmentation in vertebrate embryos.Semantic proximity Read ↗

Notch pathway regulation of chondrocyte differentiation and proliferation during appendicular and axial skeleton developmentSemantic proximity Read ↗

Nodal cis-regulatory elements reveal epiblast and primitive endoderm heterogeneity in the peri-implantation mouse embryo.Semantic proximity Read ↗

Multiple developmental defects in Engrailed-1 mutant mice: an early mid-hindbrain deletion and patterning defects in forelimbs and sternum.Semantic proximity Read ↗

The mouse rib-vertebrae mutation disrupts anterior-posterior somite patterning and genetically interacts with a Delta1 null allele.Semantic proximity Read ↗

The role of Pax-1 in axial skeleton development.Semantic proximity Read ↗

Lack of the mesodermal homeodomain protein MEOX1 disrupts sclerotome polarity and leads to a remodeling of the cranio-cervical joints of the axial skeleton.Semantic proximity Read ↗

ENU mutagenesis reveals that Notchless homolog 1 (Drosophila) affects Cdkn1a and several members of the Wnt pathway during murine pre-implantation development.Semantic proximity Read ↗

Hox genes maintain critical roles in the adult skeletonSemantic proximity Read ↗

The ventral and posterior expression of the zebrafish homeobox gene eve1 is perturbed in dorsalized and mutant embryos.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.