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Article

Genetic variation in sensitivity to estrogens and breast cancer risk.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Feb 2018

Jerry D Joseph, Shull James D, Hadsell Darryl L, Rijnkels Monique, Dunphy Karen A, Schneider Sallie S, Vandenberg Laura N, Majhi Prabin Dhangada, Byrne Celia, Trentham-Dietz Amy

Abstract excerpt

Breast cancer risk is intimately intertwined with exposure to estrogens. While more than 160 breast cancer risk loci have been identified in humans, genetic interactions with estrogen exposure remain to be established. Strains of rodents exhibit striking differences in their responses to endogenous ovarian estrogens (primarily 17β-estradiol). Similar genetic variation has been observed for synthetic estrogen...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29487996
DOI: 10.1007/s00335-018-9741-z
PMCID: PMC5936622

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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