Article
NADPH oxidase complex and IBD candidate gene studies: identification of a rare variant in NCF2 that results in reduced binding to RAC2.
Gut - 1 Jul 2012
Muise Aleixo M, Xu Wei, Guo Cong-Hui, Walters Thomas D, Wolters Victorien M, Fattouh Ramzi, Lam Grace Y, Hu Pingzhao, Murchie Ryan, Sherlock Mary, Gana Juan Cristóbal, Russell Richard K, Glogauer Michael, Duerr Richard H, Cho Judy H, Lees Charlie W, Satsangi Jack, Wilson David C, Paterson Andrew D, Griffiths Anne M, Silverberg Mark S, Brumell John H
Abstract excerpt
OBJECTIVE: The NOX2 NADPH oxidase complex produces reactive oxygen species and plays a critical role in the killing of microbes by phagocytes. Genetic mutations in genes encoding components of the complex result in both X-linked and autosomal recessive forms of chronic granulomatous disease (CGD). Patients with CGD often develop intestinal inflammation that is histologically similar to Crohn's colitis, suggesting...
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