Article
Loss of quaternary structure is associated with rapid sequence divergence in the OSBS family.
Proceedings of the National Academy of Sciences of the United States of America - 10 Jun 2014
Odokonyero Denis, Sakai Ayano, Patskovsky Yury, Malashkevich Vladimir N, Fedorov Alexander A, Bonanno Jeffrey B, Fedorov Elena V, Toro Rafael, Agarwal Rakhi, Wang Chenxi, Ozerova Nicole D S, Yew Wen Shan, Sauder J Michael, Swaminathan Subramanyam, Burley Stephen K, Almo Steven C, Glasner Margaret E
Abstract excerpt
The rate of protein evolution is determined by a combination of selective pressure on protein function and biophysical constraints on protein folding and structure. Determining the relative contributions of these properties is an unsolved problem in molecular evolution with broad implications for protein engineering and function prediction. As a case study, we examined the structural divergence of the rapidly...
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