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Article

Residues required for activity in Escherichia coli o-succinylbenzoate synthase (OSBS) are not conserved in all OSBS enzymes.

Biochemistry - 7 Aug 2012

Zhu Wan Wen, Wang Chenxi, Jipp Jacob, Ferguson Lance, Lucas Stephanie N, Hicks Michael A, Glasner Margaret E

Abstract excerpt

Understanding how enzyme specificity evolves will provide guiding principles for protein engineering and function prediction. The o-succinylbenzoate synthase (OSBS) family is an excellent model system for elucidating these principles because it has many highly divergent amino acid sequences that are <20% identical, and some members have evolved a second function. The OSBS family belongs to the enolase...

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PMID: 22775324
DOI: 10.1021/bi300753j

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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