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Article

Divergent evolution of ligand binding in the o-succinylbenzoate synthase family.

Biochemistry - 22 Oct 2013

Odokonyero Denis, Ragumani Sugadev, Lopez Mariana S, Bonanno Jeffrey B, Ozerova Nicole D S, Woodard Danae R, Machala Benjamin W, Swaminathan Subramanyam, Burley Stephen K, Almo Steven C, Glasner Margaret E

Abstract excerpt

Thermobifida fusca o-succinylbenzoate synthase (OSBS), a member of the enolase superfamily that catalyzes a step in menaquinone biosynthesis, has an amino acid sequence that is 22 and 28% identical with those of two previously characterized OSBS enzymes from Escherichia coli and Amycolatopsis sp. T-1-60, respectively. These values are considerably lower than typical levels of sequence identity among homologous...

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PMID: 24060347
DOI: 10.1021/bi401176d
PMCID: PMC3908897

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