Article
Role of an active site loop in the promiscuous activities of Amycolatopsis sp. T-1-60 NSAR/OSBS.
Biochemistry - 15 Jul 2014
McMillan Andrew W, Lopez Mariana S, Zhu Mingzhao, Morse Benjamin C, Yeo In-Cheol, Amos Jaleesia, Hull Ken, Romo Daniel, Glasner Margaret E
Abstract excerpt
The o-succinylbenzoate synthase (OSBS) family is part of the functionally diverse enolase superfamily. Many proteins in one branch of the OSBS family catalyze both OSBS and N-succinylamino acid racemization in the same active site. In some promiscuous NSAR/OSBS enzymes, NSAR activity is biologically significant in addition to or instead of OSBS activity. Identifying important residues for each reaction could...
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