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Article

Low raltegravir concentration in cerebrospinal fluid in patients with ABCG2 genetic variants.

Journal of acquired immune deficiency syndromes (1999) - 15 Aug 2014

Tsuchiya Kiyoto, Hayashida Tsunefusa, Hamada Akinobu, Kato Shingo, Oka Shinichi, Gatanaga Hiroyuki

Abstract excerpt

Adenosine triphosphate-binding cassette transporter G2 (ABCG2) is expressed on the cerebrospinal fluid (CSF) side of choroid plexus epithelial cells, which form the blood-CSF barrier. Raltegravir was recently identified as a substrate of ABCG2. In the present study, we analyzed the relationship between single-nucleotide polymorphisms of ABCB1 and ABCG2 genes and raltegravir concentrations in 31 plasma and 14 CSF...

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Source

Identifiers

PMID: 24872134
DOI: 10.1097/QAI.0000000000000222

Genes

ABCG2
ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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