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Article

Brief Report: High Peak Level of Plasma Raltegravir Concentration in Patients With ABCB1 and ABCG2 Genetic Variants.

Journal of acquired immune deficiency syndromes (1999) - 1 May 2016

Tsuchiya Kiyoto, Hayashida Tsunefusa, Hamada Akinobu, Oka Shinichi, Gatanaga Hiroyuki

Abstract excerpt

Raltegravir was recently identified to be a substrate of ATP-binding cassette transporter B1 (ABCB1) and G2 (ABCG2), which are efflux transporters and expressed in the intestines. We analyzed the relations between plasma raltegravir concentrations and single nucleotide polymorphism of ABCB1 and ABCG2 genes. The peak plasma concentration of raltegravir was significantly higher in the patients with ABCB1 4036 AG/GG...

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Share to ATP Binding Cassette Transporter, Subfamily B
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Source

Identifiers

PMID: 27097364
DOI: 10.1097/QAI.0000000000000893

Genes

ABCB1
ABCG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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