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Article

Effect of ABCC2 and ABCG2 Gene Polymorphisms and CSF-to-Serum Albumin Ratio on Ceftriaxone Plasma and Cerebrospinal Fluid Concentrations.

Journal of clinical pharmacology - 1 Dec 2018

Allegra Sarah, Cardellino Chiara Simona, Fatiguso Giovanna, Cusato Jessica, De Nicolò Amedeo, Avataneo Valeria, Bonora Stefano, D'Avolio Antonio, Di Perri Giovanni, Calcagno Andrea

Abstract excerpt

We measured ceftriaxone pharmacokinetics in patients' plasma and cerebrospinal fluid (CSF) and assessed the influence of biometric, demographic, genetic (ABCB1, ABCC2, ABCB11, ABCG2, and SLCO1A2 polymorphisms) and pathological features. Adult patients with signs and symptoms of central nervous system infections, receiving intravenous ceftriaxone, were enrolled. Ceftriaxone plasma and CSF concentrations were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29873816
DOI: 10.1002/jcph.1266

Genes

ABCC2
ABCG2
ABCB1
ABCB11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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