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Article

Determinants of darunavir cerebrospinal fluid concentrations: impact of once-daily dosing and pharmacogenetics.

AIDS (London, England) - 31 Jul 2012

Calcagno Andrea, Yilmaz Aylin, Cusato Jessica, Simiele Marco, Bertucci Roberto, Siccardi Marco, Marinaro Letizia, D'Avolio Antonio, Di Perri Giovanni, Bonora Stefano

Abstract excerpt

OBJECTIVES: To compare cerebrospinal fluid (CSF) darunavir and ritonavir concentrations in patients receiving darunavir/ritonavir 800/100 mg once daily or 600/100 mg twice daily. To determine the influence of single-nucleotide polymorphisms in the genes encoding for blood-brain barrier transporters (ABCB1 3435 C>T, ABCB1 1236 C>T, ABCB1 2677 G>T, SLCO1A2 38 A>G, SLCO1A2 516 A>C, ABCC2 -24 G>A) on darunavir and...

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Source

Identifiers

PMID: 22555164
DOI: 10.1097/QAD.0b013e3283553619

Genes

ABCB1
ABCC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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