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Article

High plasma concentrations of dolutegravir in patients with ABCG2 genetic variants.

Pharmacogenetics and genomics - 1 Nov 2017

Tsuchiya Kiyoto, Hayashida Tsunefusa, Hamada Akinobu, Oki Sakurako, Oka Shinichi, Gatanaga Hiroyuki

Abstract excerpt

The ATP-binding cassette transporters B1 (ABCB1) and G2 (ABCG2) are both expressed in the intestine and known as efflux transporters of drugs. Dolutegravir was identified recently as a substrate of both ABCB1 and ABCG2. This study aimed to determine the relations between single-nucleotide polymorphisms of ABCB1 and ABCG2 genes and plasma dolutegravir concentrations. Plasma samples were obtained from 42...

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Identifiers

PMID: 28858994
DOI: 10.1097/FPC.0000000000000308

Genes

ABCG2
ABCB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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