Article
Population pharmacokinetic analysis and pharmacogenetics of raltegravir in HIV-positive and healthy individuals.
Antimicrobial agents and chemotherapy - 1 Jun 2012
Arab-Alameddine Mona, Fayet-Mello Aurélie, Lubomirov Rubin, Neely Michael, di Iulio Julia, Owen Andrew, Boffito Marta, Cavassini Matthias, Günthard Huldrych F, Rentsch Katharina, Buclin Thierry, Aouri Manel, Telenti Amalio, Decosterd Laurent Arthur, Rotger Margalida, Csajka Chantal
Abstract excerpt
The objectives of this study were to characterize raltegravir (RAL) population pharmacokinetics in HIV-positive (HIV(+)) and healthy individuals, identify influential factors, and search for new candidate genes involved in UDP glucuronosyltransferase (UGT)-mediated glucuronidation. The pharmacokinetic analysis was performed with NONMEM. Genetic association analysis was performed with PLINK using the relative...
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