Article
Effect of Genetic Polymorphisms of ABCB1, ABCG2, and SLC22A1 on the Steady-State Plasma Concentrations of Lamotrigine in Treatment-Resistant Depressed Patients Treated With Lamotrigine Augmentation Therapy.
Clinical neuropharmacology - 1 Jan 2000
Tomori Yoko, Suzuki Takeshi, Mihara Kazuo, Nagai Goyo, Kagawa Shoko, Nakamura Akifumi, Nemoto Kenji, Kondo Tsuyoshi
Abstract excerpt
OBJECTIVES: The authors have demonstrated that a plasma lamotrigine concentration of 12.7 μmol/L may be a threshold for a good therapeutic response to lamotrigine augmentation therapy in treatment-resistant depressed patients. Lamotrigine is a substrate of P-glycoprotein, breast cancer resistant protein and organic cation transporter 1, which are encoded by ABCB1 , ABCG2 , and SLC22A1 , respectively. There have...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.