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Article

CYP2B6 genetic variants are associated with nevirapine pharmacokinetics and clinical response in HIV-1-infected children.

AIDS (London, England) - 18 Oct 2007

Saitoh Akihiko, Sarles Elizabeth, Capparelli Edmund, Aweeka Francesca, Kovacs Andrea, Burchett Sandra K, Wiznia Andrew, Nachman Sharon, Fenton Terence, Spector Stephen A

Abstract excerpt

BACKGROUND: Cytochrome P450 2B6 (CYP2B6)-G516T genotype is associated with altered activity of hepatic CYP2B6 and efavirenz pharmacokinetics, but the relationship between the CYP2B6-G516T genotype and nevirapine (NVP) pharmacokinetics in plasma and cerebrospinal fluid (CSF) is limited. METHODS: In 126 children who received NVP and protease inhibitors from PACTG 366 and 377 cohorts, CYP2B6 and ATP-binding...

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Source

Identifiers

PMID: 18090046
DOI: 10.1097/QAD.0b013e3282ef9695

Genes

ABCB1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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