Article
The WWOX gene modulates high-density lipoprotein and lipid metabolism.
Circulation. Cardiovascular genetics - 1 Aug 2014
Iatan Iulia, Choi Hong Y, Ruel Isabelle, Reddy M V Prasad Linga, Kil Hyunsuk, Lee Jaeho, Odeh Mohammad Abu, Salah Zaidoun, Abu-Remaileh Muhannad, Weissglas-Volkov Daphna, Nikkola Elina, Civelek Mete, Awan Zuhier, Croce Carlo M, Aqeilan Rami I, Pajukanta Päivi, Aldaz C Marcelo, Genest Jacques
Abstract excerpt
BACKGROUND: Low levels of high-density lipoprotein (HDL) cholesterol constitutes a major risk factor for atherosclerosis. Recent studies from our group reported a genetic association between the WW domain-containing oxidoreductase (WWOX) gene and HDL cholesterol levels. Here, through next-generation resequencing, in vivo functional studies and gene microarray analyses, we investigated the role of WWOX in HDL and...
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