Article
WW-domain-containing oxidoreductase is associated with low plasma HDL-C levels.
American journal of human genetics - 1 Aug 2008
Lee Jenny C, Weissglas-Volkov Daphna, Kyttälä Mira, Dastani Zari, Cantor Rita M, Sobel Eric M, Plaisier Christopher L, Engert James C, van Greevenbroek Marleen M J, Kane John P, Malloy Mary J, Pullinger Clive R, Huertas-Vazquez Adriana, Aguilar-Salinas Carlos A, Tusie-Luna Teresa, de Bruin Tjerk W A, Aouizerat Bradley E, van der Kallen Carla C J, Croce Carlo M, Aqeilan Rami I, Marcil Michel, Viikari Jorma S A, Lehtimäki Terho, Raitakari Olli T, Kuusisto Johanna, Laakso Markku, Taskinen Marja-Riitta, Genest Jacques, Pajukanta Päivi
Abstract excerpt
Low serum HDL-cholesterol (HDL-C) is a major risk factor for coronary artery disease. We performed targeted genotyping of a 12.4 Mb linked region on 16q to test for association with low HDL-C by using a regional-tag SNP strategy. We identified one SNP, rs2548861, in the WW-domain-containing oxidoreductase (WWOX) gene with region-wide significance for low HDL-C in dyslipidemic families of Mexican and European...
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