Human genetics of HDL: Insight into particle metabolism and function

Abstract excerpt

Levels of high-density lipoprotein cholesterol (HDL-C) are inversely related to cardiovascular disease risk and HDL particles possess a variety of anti-atherosclerotic properties. However, several recent clinical trials aimed at raising HDL-C levels have failed to yield the expected improvement in clinical outcomes, highlighting the need for a better understanding of HDL particle function and metabolism. Human...